Regulatory effect of anisotropic structure on cardiomyocyte maturation

Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to limited regenerative capacity adult heart, treatments based on human pluripotent stem cells (hPSCs) have become focus a great deal research. Human cell–derived cardiomyocytes (hPSC-CMs) can provide an ideal cell source for CVD model construction, cardiac tissue repair, and drug cardiotoxicology However, immaturity hPSC-CMs seriously restricts its clinical application. The maturation depends orderly arrangement myofilaments increase expression connexin, so geometric regulation bioengineering substrate one keys engineered myocardial tissue. This review focuses key indicators anisotropic structures provided by biomaterials improve characteristics cardiomyocytes, as promote looks forward development direction in this field.